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Rabbit Anti-EXOSC10 Polyclonal Antibody
- Description
- Documentation
- Citations
| Cat No | BSPA-1840 |
| Conjugate | |
| Type | Polyclonal Antibody |
| Source | Rabbit |
| Size | 1 mg |
| Application | ELISA; WB |
| Format | Liquid |
| Concentration | Please refer to the vial lable for the specific concentration. |
| Buffer | Supplied in PBS. |
| Species | Human |
| Storage | Store at -20 degree. Avoid repeted freeze/thaw cycl. |
| Synonyms | EXOSC10;exosome component 10;PMSCL2, polymyositis/scleroderma autoantigen 2, 100kDa;p2;p3;p4;PM Scl;PM/Scl 100;polymyositis/scleroderma autoantigen 2 (100kD);RRP6;Rrp6p;autoantigen PM-SCL;autoantigen PM/Scl 2;polymyositis/scleroderma autoanti |
| Purification | |
| Note | Tis product l is eeze eezeleezeegrrch useeze ly, no useeze huma, apeut agnost apcal. |
| MolecularWeight | |
| Description | |
| Background | Putative catalytic component of the RNA exosome complex which has 3, 5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3-5 exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. |
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.