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Cat No | BMA-870 |
Conjugate | |
Type | 重组兔多抗 |
Source | Rabbit |
Size | 50 uL |
Application | WB |
Format | Liquid |
Concentration | Please refer to the vial lable for the specific concentration. |
Buffer | Supplied in PBS with 0.05% sodium azide,0.2% BSA,40% glycerol,pH7.4. |
Species | Human |
Storage | Store at -20℃. Avoid freeze / thaw cycles. |
Synonyms | B7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274 |
Purification | ≥95% purity by SDS-PAGE |
MolecularWeight | Refer to figures |
Description | |
Background | Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies. |