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Rabbit anti-Human PD-L1/CD274 Monoclonal Antibody

Cat NoBMA-870
Conjugate
Type重组兔多抗
SourceRabbit
Size50 uL
ApplicationWB
FormatLiquid
ConcentrationPlease refer to the vial lable for the specific concentration.
BufferSupplied in PBS with 0.05% sodium azide,0.2% BSA,40% glycerol,pH7.4.
SpeciesHuman
StorageStore at -20℃. Avoid freeze / thaw cycles.
SynonymsB7-H;B7H1;PDL1;PD-L1;PDCD1L1;PDCD1LG1;CD274
Purification≥95% purity by SDS-PAGE
MolecularWeightRefer to figures
Description
BackgroundProgrammed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that suppresses immune system. PD-L1 is expressed in hematopoietic and non-hematopoietic cells including T cells and B cells and various types of tumor cells. PD-L1 binds to its receptor Programmed death 1 (PD1). During infection or inflammation, PD1-PD-L1 interaction is important for preventing autoimmunity. In tumor microenvironments, PD1-PD-L1 interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human cancers. In recent years, PD-L1 has become an important biomarker and immunotherapy target for many types of malignancies.
We can offer labeled proteins/antibodies using a broad range of intensely fluorescent dyes and labels including FITC, Biotin, Alexa Fluor, Rhodamine B, Cy, Co-Au.